Dr. Ron’s Research Review – June 4, 2014

© 2014

This week’s research review focuses on upper Hypothyroidism and Marginal Pretarsal Edema


In 1970 NEJM, Dr. Katz described “Marginal Pretarsal Edema” as a sign of hypothyroidism where abnormal mucopolysaccharide infiltrate causes the upper eyelid to bulge.
Katz describes “examination with lateral illumination of the almost closed eye, the skin overlying the inferior 2 or 3 mm of the margin of the upper lid is seen to bulge noticeably and to have the appearance of being distended by sub-epidermal infiltrate.” (Katz, 1970)

Hypothyroidism is listed in Eyelid Swelling by Merck, which is last in an extensive table of causes with allergies being the first on the list.

On the same page are two other interesting articles.

The cause of pre-ecclampsia may be related to the natiuretic properties of progesterone. (Matz, 1970)

Trigeminal neuropathy may be related to connective-tissue disease, such as Sjogren’s syndrome or systemic sclerosis. (Gumpel, 1970)

Dr. Ron



Edema of the margin of the upper eyelid (pretarsal) in hypothyroidism.
            (Katz, 1970) Download

Trigeminal sensory neuropathy in connective-tissue disease.
            (Gumpel, 1970)

Salt depletion in pregnancy.
            (Matz, 1970)



Gumpel, JM (1970), ‘Trigeminal sensory neuropathy in connective-tissue disease.’, N Engl J Med, 282 (9), 514. PubMedID: 4312552
Katz, M (1970), ‘Edema of the margin of the upper eyelid (pretarsal) in hypothyroidism.’, N Engl J Med, 282 (9), 514-15. PubMedID: 5411878
Matz, R (1970), ‘Salt depletion in pregnancy.’, N Engl J Med, 282 (9), 514. PubMedID: 5411877