Vitamin E Abstracts 1

© 2012

Vitamin E and Habitual Abortion

         (Bacharach 1940) Download

Effect of Vitamin E Deficiency on the Thyroid

            (Barrie 1936) Download

SINGER1 found that vitamin E deficiency produced hypoplasia of the thyroid in rats. I have noticed what appears to be cretinism in the young of vitamin E-deficient rats. Female rats kept on an E-free diet usually have an initial fertility and produce a litter of living young before becoming absolutely sterile ; the litters of such rats or of rats which have been proved sterile and have then been given a small dose of vitamin E concentrate, just sufficient to produce a litter of two or three, show definite signs of thyroid deficiency.

Vitamin E in Habitual Abortion

            (Currie 1937) Download

An increased incorporation of P32 into nucleic acids by vitamin E-deficient rabbits

            (Day, Dinning et al. 1956) Download

Vitamin E deficiency in the monkey. I. Muscular dystrophy, hematologic changes, and the excretion of urinary nitrogenous constituents

            (Dinning and Day 1957) Download

Vitamin E deficiency in the monkey. II. Tissue concentrations of nucleic acids and creatine

            (Dinning and Day 1957) Download

Vitamin E deficiency in the monkey. III. The metabolism of sodium formate-C14

            (Dinning and Day 1958) Download


Alpha-tocopherol: looking beyond an antioxidant

            (Engin 2009) Download

Vitamin E is an important natural antioxidant, and its most common and biologically active form is alpha-tocopherol. In addition to this, specific regulatory effects of vitamin E have been revealing. The body exerts a certain effort to regulate its tissue levels with specific tocopherol transport proteins and membrane receptors. Antiproliferative and protein kinase C-suppressing effects of alpha-tocopherol have been previously demonstrated, which have not been mimicked by beta-tocopherol or probucol. Protein kinase C promises to be an important area of interest in the means of glaucoma and cataractogenesis. It has been shown in different models that retinal vascular dysfunction due to hyperglycemia could be prevented by alpha-tocopherol via the diachylglycerol-protein kinase C pathway. Glutamate transporter activity has been shown to be modulated by protein kinase C. This pathway is also important in intraocular pressure-lowering effects of prostaglandin and its analogs in glaucoma therapy. Filtran surgery became another possible area of usage of alpha-tocopherol since its antiproliferative effect has been demonstrated in human Tenon's capsule fibroblasts. Prevention of posterior capsule opacification is another area for future studies. It is evident that when correct and safe modulation is the objective, alpha-tocopherol merits a concern beyond its mere antioxidant properties.

Vitamin E deficiency in the monkey. V. Estimated requirements and the influence of fat deficiency and antioxidants on the syndrome

            (Fitch and Dinning 1963) Download

Synthesis of alpha-Tocopherol (Vitamin E)

            (Karrer, Fritzche et al. 1938) Download

WE have described1 the synthesis of a compound, obtained by letting phytyl-bromide react with trimethyl-hydroquinone. We also expressed the opinion that this substance might be the racemic form of α-tocopherol.

The Cure of Nutritional Muscular Dystrophy in the Rabbit by Alpha-Tocopherol And Its Effect on Creatine Metabolism

            (Mackenzie and McCollum 1940) Download


Vitamin E deficiency in the monkey. IV. Further studies of the anemia with emphasis on bone marrow morphology

            (Porter, Fitch et al. 1962) Download

Should spontaneous abortion be prevented? Vitamin E in its management

            (Shute 1960) Download

Effect of Vitamin E Deficiency on the Thyroid Gland of the Rat

            (Singer 1936) Download

Dietary Requirements For Fertility And Lactation

            (Sure 1928) Download

The effects of vitamin E and of methylene blue on the manifestations of oxygen poisoning in the rat

            (Taylor 1956) Download

           


References

Bacharach, A. L. (1940). "Vitamin E and Habitual Abortion." Br Med J 1(4143): 890.

Barrie, M. M. O. (1936). "Effect of Vitamin E Deficiency on the Thyroid." Nature 139(3511): 286.

Currie, D. (1937). "Vitamin E in Habitual Abortion." Br Med J 2(4015): 1218-9.

Day, P. L., J. S. Dinning, et al. (1956). "An increased incorporation of P32 into nucleic acids by vitamin E-deficient rabbits." J Biol Chem 222(1): 215-7.

Dinning, J. S. and P. L. Day (1957). "Vitamin E deficiency in the monkey. I. Muscular dystrophy, hematologic changes, and the excretion of urinary nitrogenous constituents." J Exp Med 105(5): 395-402.

Dinning, J. S. and P. L. Day (1957). "Vitamin E deficiency in the monkey. II. Tissue concentrations of nucleic acids and creatine." J Nutr 63(3): 393-7.

Dinning, J. S. and P. L. Day (1958). "Vitamin E deficiency in the monkey. III. The metabolism of sodium formate-C14." J Biol Chem 233(1): 240-2.

Engin, K. N. (2009). "Alpha-tocopherol: looking beyond an antioxidant." Mol Vis 15: 855-60.

Fitch, C. D. and J. S. Dinning (1963). "Vitamin E deficiency in the monkey. V. Estimated requirements and the influence of fat deficiency and antioxidants on the syndrome." J Nutr 79: 69-78.

Karrer, P., H. Fritzche, et al. (1938). "Synthesis of alpha-Tocopherol (Vitamin E)." Nature 141: 1057-1057.

Mackenzie, C. G. and E. V. McCollum (1940). "The Cure of Nutritional Muscular Dystrophy in the Rabbit by Alpha-Tocopherol And Its Effect on Creatine Metabolism." J. Nutr. 19: 345-362.

Porter, F. S., C. D. Fitch, et al. (1962). "Vitamin E deficiency in the monkey. IV. Further studies of the anemia with emphasis on bone marrow morphology." Blood 20: 471-7.

Shute, E. V. (1960). "Should spontaneous abortion be prevented? Vitamin E in its management." Can Med Assoc J 82: 72-6.

Singer, E. (1936). "Effect of Vitamin E Deficiency on the Thyroid Gland of the Rat." J Physiol

 87(3): 287–290.

Sure, B. (1928). "Dietary Requirements For Fertility And Lactation." J. Biol. Chem. 76: 659-671.

Taylor, D. W. (1956). "The effects of vitamin E and of methylene blue on the manifestations of oxygen poisoning in the rat." J Physiol 131(1): 200-6.