Uric Acid Abstracts 3 - Salicylate

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Influence of Salicylic Acid and its Salts on the Excretion of Uric Acid

         (Haig 1888) Download

Gout; observations on the effects of drugs on plasma uric acid and urinary uric acid

         (Kersley, Mandel et al. 1951) Download

Effect of ACTH and sodium salicylate on the urinary uric acid: creatinine ratio, and circulating eosinophils in man

         (Marson 1953) Download

The effects of oral salicylate on serum uric acid levels

         (Price and Ford 1963) Download

Thirteen males and six females were given 40 grains of oral salicylate daily for six days. The serum uric acid of 16 of the 19 subjects fell, the mean post-treatment level being 1.1 mg. % less than the control mean. In five males and five females, administration of 20 grains of oral salicylate daily for six days resulted in a uniform rise of serum uric acid, the post-treatment mean being 1.4 mg. % above the pretreatment mean. Salicylate therapy in common dosage may therefore falsely elevate or depress serum uric acid levels. An accurate evaluation of a serum uric acid level can be made only if the patient is not under the influence of salicylates.

Study of the paradoxical effects of salicylate in low, intermediate and high dosage on the renal mechanisms for excretion of urate in man

         (Yu and Gutman 1959) Download


References

Haig, A. (1888). "Influence of Salicylic Acid and its Salts on the Excretion of Uric Acid." Med Chir Trans 71: 125-38 PMID: 20896720

Kersley, G. D., L. Mandel, et al. (1951). "Gout; observations on the effects of drugs on plasma uric acid and urinary uric acid." Ann Rheum Dis 10(3): 353-8 PMID: 14878356

Marson, F. G. (1953). "Effect of ACTH and sodium salicylate on the urinary uric acid: creatinine ratio, and circulating eosinophils in man." Ann Rheum Dis 12(4): 296-300 PMID: 13125229

Price, G. E. and D. K. Ford (1963). "The effects of oral salicylate on serum uric acid levels." Can Med Assoc J 88: 1065-7 PMID: 13986132

Yu, T. F. and A. B. Gutman (1959). "Study of the paradoxical effects of salicylate in low, intermediate and high dosage on the renal mechanisms for excretion of urate in man." J Clin Invest 38(8): 1298-315 PMID: 13673086