UVBI Abstracts 2

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Use of ultraviolet blood irradiation in the treatment of bursitis and tendinitis calcarea.
            (Neff and Anderson, 1951) Download
The use of ultraviolet blood irradiation in treating bursitis and tendinitis calcarea has been presented and discussed in 17 cases with 88.2 percent complete relief of symptoms.

Ultraviolet irradiation of blood in man; studies of sixty-eight patients.
            (Schwartz et al., 1952) Download
Comparatively recent interest in ultraviolet rays as a means of sterilization stimulated us to investigate the value of this therapeutic method. The fountainhead of interest in the beneficial effects of ultraviolet irradiation of blood is E. K. Knott,1 who, working from the premise that ultraviolet rays have bactericidal properties, devised an ingenious apparatus for the purpose of irradiating whole blood. He recognized early "that the source of the ultraviolet energy was inconstant and varied widely" and would "produce variable results and often a failure to obtain measurable results." Because of this, "A source of ultraviolet of known intensity was sought that could be easily controlled so that a uniform dosage could be achieved and duplicated at will."

Ultraviolet blood irradiation: Is it time to remember "the cure that time forgot"
            (Wu et al., 2016) Download
Ultraviolet blood irradiation (UBI) was extensively used in the 1940s and 1950s to treat many diseases including septicemia, pneumonia, tuberculosis, arthritis, asthma, and even poliomyelitis. The early studies were carried out by several physicians in USA and published in the American Journal of Surgery. However, with the development of antibiotics, the use of UBI declined and it has now been called "the cure that time forgot." Later studies were mostly performed by Russian workers, and in other Eastern countries, and the modern view in Western countries is that UBI remains highly controversial. This review discusses the potential of UBI as an alternative approach to current methods used to treat infections, as an immune-modulating therapy and as a method for normalizing blood parameters. Low and mild doses of UV kill microorganisms by damaging the DNA, while any DNA damage in host cells can be rapidly repaired by DNA repair enzymes. However, the use of UBI to treat septicemia cannot be solely due to UV-mediated killing of bacteria in the bloodstream, as only 5-7% of blood volume needs to be treated with UV to produce the optimum benefit, and higher doses can be damaging. There may be some similarities to extracorporeal photopheresis (ECP) using psoralens and UVA irradiation. However, there are differences between UBI and ECP in that UBI tends to stimulate the immune system, while ECP tends to be immunosuppressive. With the recent emergence of bacteria that are resistant to all known antibiotics, UBI should be more investigated as an alternative approach to infections, and as an immune-modulating therapy.

 


References

Neff, FE and CM Anderson (1951), ‘Use of ultraviolet blood irradiation in the treatment of bursitis and tendinitis calcarea.’, Am J Surg, 81 (6), 622-28. PubMed: 14829721
Schwartz, SO, et al. (1952), ‘Ultraviolet irradiation of blood in man; studies of sixty-eight patients.’, J Am Med Assoc, 149 (13), 1180-83. PubMed: 14938136
Wu, X, X Hu, and MR Hamblin (2016), ‘Ultraviolet blood irradiation: Is it time to remember “the cure that time forgot”’, J Photochem Photobiol B, 157 89-96. PubMed: 26894849