Organotherapy Articles 7

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Doseage of Gonad Stimulating Hormones

         (1938) Download

No standard doseage has yet been adopted.

Liver Extract in the Treatment of Hypertension

         (Althausen, Kerr et al. 1929) Download

The treatment of hypertension with liver extract brings about a considerable lowering of the blood-pressure and affords complete or marked symptomatic relief in a majority of cases.

The value of liver-extract therapy in hypertension at present is two-fold.  From the patient’s point of view, it is justified in favorable cases on account of symptomatic relief, which in such cases is unequalled by any therapeutic procedure known heretofore.  In cases which respond by lowering of blood pressure, it also serves to take off, or at least to diminish, the extra load imposed ont eh heart by hypertension.  In this way, secondary cardiovascular renal degenerative changes probably can be prevented or their progress slowed down.

Clinical Syndromes due to Suprarenal Disease Hypoadrenia

         (Cohoe 1922) Download

Adrenal Extract, Infectious Diseases, Depletion—

The possible relation of the marked prostration following an attack of influenza to suptrarenal insufficiency has been the subject of considerable discussion.  Autopsy records appear to indicate that lesions in the glands are present in a large proportion of the fatal cases.


Recent Advances in Control of Arterial Pressure

         (Halls Dally 1929) Download

Evidence that liver extract is of benefit for reduction of high blood-pressure and to stimulate hepatic detoxication in certain groups of cases associated with toxemia, especially the toxemias of pregnancy, is highly suggestive. Liver Extract

Remarks on the Pathogenesis of Graves' Disease

         (Marine 1930) Download

... so far have found only one that has any notable effect, that feeding a glycerol emulsion of very fresh or suprarenal cortex (glands from which 90 percent of medulla has been removed) cause a striking gain in body weight and in muscle strength.  These effects quite constantly begin to appear after two weeks of feeding

The Effect of Pancreatic Tissue Extract on Muscle Pain of Ischemic Origin (Intermittent Claudication)

         (Roth 1933) Download

…Roth, Barker, and Brown conclude that the pancreatic tissue extract used at the Mayo Clinic is “…the only substance now known which has had definite and striking effect on the symptoms of intermittent claudication.”

Myasthenia Gravis Treatment with Anterior Pituitary Extract

         (Simoni 1935) Download

This report of subcutaneous injections of anterior pituitary extract in the treatment of myesthenia gravis is a preliminary study. The number of cases available is too small and the period of time over which they have been observed is too short to permit general conclusions, but the responses so far are very encouraging. Both of these patients presented undoubted clinical evidence of myasthenia gravis. In both instances the response to treatment with anterior pituitary extract was prompt and complete, and a relapse promptly followed when the injections were omitted. On resumption of treatment the symptoms disappeared in both cases.


The Question of Eczema and the Exudative Diathesis

         (von Zumbusch 1927) Download

Some years ago pupils of von Zumbusch showed that the injection of an albumin-free spleen extract, even in small amounts, diminished the number of eosinophils in dermatoses associated with eosinophilis, and that accompanying pruritus was stopped.  A case of generalized desquamative erythrodermia was cured by this method.  Von Zumbusch mentions cases of eczema of ten years’ standing in which spleen extract corrected the condition after every other treatment had failed.

Treatment of Fractures: Further Observations on the use of Splenic Extract

         (Wheeldon 1936) Download

Wheeldon also reports on the use of a spleen extract in forty-five cases of fracture with non-union, in which they were only three failures.  He suggests that spleen therapy in these cases probably acts by increasing calcium retention.  Here, of course, an oral extract was used.

Treatment of Angina Pectoris With a Tissue Vasodilator Extract - Preliminary Report

         (Wolffe, Findlay et al. 1931) Download

Angina Pectoris is another distressing and common syndrome that may be modified by this treatment.  The pain of angina pectoris, like that of intermittent claudication, apparently is due to muscular ischemia.  This extract is capable of bringing about a remarkable dilation of the coronary vessels so that the ischemia is relieved with gratifying results.  Wolffe and associates obtained clinical relief with their extract in 56 per cent, partial relief in 30 per cent, and failure in only 14 per cent of their cases. (Pancreas Extract)


Pancreatic Extract (Enzyme-Free) in the Treatment of Diabetic and Arteriosclerotic Gangrene

         (Wolffe 1939) Download

Very recently Wolffe has reported on the use of an enzyme-free pancreatic extract in the treatment of one hundred cases of gangrene.  Complete healing was obtained in as many as 75 per cent.  This extract seemed not only to produce an early arrest of pathologic processes but to stimulate repair more rapidly and more completely than any other conservative method.  The usual procedure with Panocrin-C is to give 1 cc. (20 units0 by subcutaneous or intramuscular injection once or twice daily.  As much as 1 cc. every four hours may be given on occasion.

Patients in my series of 100 cases of gangrene…seemed to do very well, presenting about 75 per cent of complete healing…Pancreatic extract (enzyme-free) proved of great value as an additional therapeutic agent in the management of diabetic and arteriosclerotic gangrene.  It not only produces an early arrest of pathologic processes, but seems to stimulate repair more rapidly and more completely than any other conservative method in my experience.


References

(1938). "Doseage of Gonad Stimulating Hormones." JAMA 111: 1584. [PMID:

Althausen, T. L., W. J. Kerr, et al. (1929). "Liver Extract in the Treatment of Hypertension." Am. Jour. Med. Sc. cixxvii: 398. [PMID:

Cohoe, B. A. (1922). "Clinical Syndromes due to Suprarenal Disease Hypoadrenia." Endocrinology and Metabolism II: 321. [PMID:

Halls Dally, J. F. (1929). "Recent Advances in Control of Arterial Pressure." American Medicine xxxv: 353. [PMID:

Marine, D. (1930). "Remarks on the Pathogenesis of Graves' Disease." Am. Jour. Med. Sc. clxxx: 767. [PMID:

Roth, G. (1933). "The Effect of Pancreatic Tissue Extract on Muscle Pain of Ischemic Origin (Intermittent Claudication)." Proc. Staff Meetings of Mayo Clinic 1033(Viii): 481. [PMID:

Simoni, R. E. (1935). "Myasthenia Gravis Treatment with Anterior Pituitary Extract." JAMA 104(19): 2065. [PMID:

von Zumbusch, L. (1927). "The Question of Eczema and the Exudative Diathesis." Urol. And Cutan. Rev. xxxi: 750. [PMID:

Wheeldon, T. F. (1936). "Treatment of Fractures: Further Observations on the use of Splenic Extract." Surg., Gynec., and Obat ixiii: 761. [PMID:

Wolffe, J. B. (1939). "Pancreatic Extract (Enzyme-Free) in the Treatment of Diabetic and Arteriosclerotic Gangrene." Am. Jour. Surg. xliii: 109. [PMID:

Wolffe, J. B., D. Findlay, et al. (1931). "Treatment of Angina Pectoris With a Tissue Vasodilator Extract - Preliminary Report." Ann Int. Med: 625. [PMID: