Organotherapy Articles 1

© 2013

Endocrine Therapy

         (1925) Download

A MEETING of the Royal Society of Medicine was held on March 31st, Sir William Hale-White being in the chair, when Dr. W. Langdon Brown opened a special discussion on Endocrine Therapy.

The nature of the vaso-dilator constituents of certain tissue extracts

         (Best, Dale et al. 1927) Download

Histamine and choline have been isolated from alcoholic extracts of fresh liver and lung,in quantities suficient to account for the immediate vaso-dilator activities of those extracts. Histamine is responsible for the greater part of this activity, and is present in remarkably large amount in the extract from lung. The physiological significance of its occurrence is discussed.

The effect of anterior pituitary extracts on the insulin content of the pancreas

         (Best, Campbell et al. 1939) Download

The effect of insulin and anterior pituitary extract on the insulin content of the pancreas and the histology of the islets

         (Best, Campbell et al. 1942) Download

Special Discussion on Endocrine Therapy

         (Brown 1925) Download

Uses and Abuses of Endocrine Therapy

         (Brown 1925) Download


The modification of the action of insulin by pituitary extract and other substances

         (Burn 1923) Download

Increased lymph histaminase in adrenalectomized cats and its restoration by adrenocortical extract but not by adrenaline

         (Carlsten and Wood 1951) Download

Observations on extracts of beef adrenal cortex and elasmobranch interrenal body

         (Cleghorn 1932) Download

The effects of injections of extracts of adrenal cortex on the development and sex functions of the albino mouse

         (Cleghorn 1932) Download

The composition and action of orchitic extracts

         (Dixon 1901) Download

The effect of anterior pituitary extracts, desiccated thyroid, growth-hormone preparations and ACTH on the extractable secretin of the intestines of hypophysectomized and intact rats

         (Dorchester and Haist 1953) Download

Special Discussion on Endocrine Therapy

         (Gardiner-Hill 1925) Download

The antagonism between insulin and posterior lobe pituitary extract

         (Griffiths 1941) Download

The physiological effects of extracts of nervous tissues

         (Halliburton 1901) Download


Practical Hormone Therapy A Manual of Organotherapy for General Practitioners

         (Harrower 1914) Download

Special Discussion on Endocrine Therapy

         (Higgins 1925) Download

The action of pituitary posterior lobe extracts on different parts of the circulatory system

         (Holtz 1932) Download

Discussion On The Uses And Abuses Of Endocrine Therapy

         (Langdon Brown 1925) Download

Organotherapy

         (Langdon-Brown 1938) Download

Hypothyroidism and thyroid substitution: historical aspects

         (Lindholm and Laurberg 2011) Download

The last part of the 19th century was a period of great achievements in medicine and endocrinology. The thyroid gland evolved from being considered a rudimentary structure to an organ related to specific diseases. The singular importance of iodine became acknowledged. Graves-Basedow's disease was described. Surgical treatment evolved with extraordinary speed. Theodor Kocher observed that the clinical picture in patients after total thyroidectomy was similar to the one seen in cretinism. In 1850, the first case of hypothyroidism or myxedema was described. Less than 50 years later, effective treatment was introduced. Another 50 years later, autoimmune thyroiditis was ascertained as the most frequent cause of hypothyroidism (in areas with no iodine deficiency). This paper gives a short survey of the history of hypothyroidism and its treatment.


Special Discussion on Endocrine Therapy

         (McDonagh 1925) Download

The action of embryonic extracts on the sex organs

         (Meyerhof and Zironi 1940) Download

The effect on blood-pressure of organ extracts

         (Miller and Miller 1911) Download

Special Discussion on Endocrine Therapy

         (Miller 1925) Download

The action of extracts from the anterior lobe of the pituitary gland on the islets of Langerhans in the pancreas of the mouse

         (Mount 1951) Download

On the Physiological Action of Extracts of Pituitary Body and certain other Glandular Organs: Preliminary Communication

         (Oliver and Schafer 1895) Download

The physiological effects of extracts of nervous tissues

         (Osborne and Vincent 1900) Download

On the Therapeutics of Organic Extracts

         (Paton 1915) Download

Special Discussion on Endocrine Therapy

         (Pugh 1925) Download

Special Discussion on Endocrine Therapy

         (Ray 1925) Download


The "pancreotropic" action of anterior pituitary extracts

         (Richardson and Young 1937) Download

Insulin-like effect of anterior pituitary extract in accelerating the transfer of glucose across the blood-aqueous barrier

         (Ross 1955) Download

The physiological effects of extracts of the pituitary body

         (Schafer and Vincent 1899) Download

Organotherapy

         (Sheppard 1923) Download

Changes in Blood Serum Calcium Following the Administration of Parathyroid Extract

         (Sherrill and Copp 1926) Download

Pancreatic organotherapy for diabetes, 1889-1921

         (Tattersall 1995) Download

A Study of the Parathyroid Glandules in Paralysis agitans

         (Thompson 1906) Download

Special Discussion on Endocrine Therapy

         (Vincent 1925) Download

Special Discussion on Endocrine Therapy

         (Walker 1925) Download


References

(1925). "Endocrine Therapy." Lancet. [PMID:

Best, C. H., J. Campbell, et al. (1939). "The effect of anterior pituitary extracts on the insulin content of the pancreas." J Physiol 97(2): 200-6. [PMID: 16995154]

Best, C. H., J. Campbell, et al. (1942). "The effect of insulin and anterior pituitary extract on the insulin content of the pancreas and the histology of the islets." J Physiol 101(1): 17-26. [PMID: 16991546]

Best, C. H., H. H. Dale, et al. (1927). "The nature of the vaso-dilator constituents of certain tissue extracts." J Physiol 62(4): 397-417. [PMID: 16993860]

Brown, L. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 25-48. [PMID: 19984361]

Brown, L. (1925). "Uses and Abuses of Endocrine Therapy." British Med J. [PMID:

Burn, J. H. (1923). "The modification of the action of insulin by pituitary extract and other substances." J Physiol 57(5): 318-29. [PMID: 16993576]

Carlsten, A. and D. R. Wood (1951). "Increased lymph histaminase in adrenalectomized cats and its restoration by adrenocortical extract but not by adrenaline." J Physiol 112(1-2): 142-8. [PMID: 14825187]

Cleghorn, R. A. (1932). "Observations on extracts of beef adrenal cortex and elasmobranch interrenal body." J Physiol 75(4): 413-27. [PMID: 16994326]

Cleghorn, R. A. (1932). "The effects of injections of extracts of adrenal cortex on the development and sex functions of the albino mouse." J Physiol 76(2): 193-200. [PMID: 16994344]

Dixon, W. E. (1901). "The composition and action of orchitic extracts." J Physiol 26(3-4): 244-76. [PMID: 16992578]

Dorchester, J. E. and R. E. Haist (1953). "The effect of anterior pituitary extracts, desiccated thyroid, growth-hormone preparations and ACTH on the extractable secretin of the intestines of hypophysectomized and intact rats." J Physiol 119(2-3): 266-73. [PMID: 13035751]

Gardiner-Hill, H. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 36-8. [PMID: 19984365]

Griffiths, M. (1941). "The antagonism between insulin and posterior lobe pituitary extract." J Physiol 100(1): 112-6. [PMID: 16991508]

Halliburton, W. D. (1901). "The physiological effects of extracts of nervous tissues." J Physiol 26(3-4): 229-43. [PMID: 16992577]

Harrower, H. (1914). Practical Hormone Therapy A Manual of Organotherapy for General Practitioners. London, Bailliere, Tindall and Cox.

Higgins (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 47. [PMID: 19984370]

Holtz, P. (1932). "The action of pituitary posterior lobe extracts on different parts of the circulatory system." J Physiol 76(2): 149-69. [PMID: 16994340]

Langdon Brown, I. W. (1925). "Discussion On The Uses And Abuses Of Endocrine Therapy." British Med J. [PMID:

Langdon-Brown, W. (1938). "Organotherapy." Br Med J 2(4058): 773-6. [PMID: 20781804]

Lindholm, J. and P. Laurberg (2011). "Hypothyroidism and thyroid substitution: historical aspects." J Thyroid Res 2011: 809341. [PMID: 21760981]

McDonagh, J. E. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 41-7. [PMID: 19984368]

Meyerhof, H. L. and A. Zironi (1940). "The action of embryonic extracts on the sex organs." J Physiol 97(4): 495-508. [PMID: 16995180]

Miller, H. C. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 41. [PMID: 19984367]

Miller, J. L. and E. M. Miller (1911). "The effect on blood-pressure of organ extracts." J Physiol 43(3-4): 242-6. [PMID: 16993108]

Mount, L. E. (1951). "The action of extracts from the anterior lobe of the pituitary gland on the islets of Langerhans in the pancreas of the mouse." J Physiol 114(1-2): 1-7. [PMID: 14861778]

Oliver, G. and E. A. Schafer (1895). "On the Physiological Action of Extracts of Pituitary Body and certain other Glandular Organs: Preliminary Communication." J Physiol 18(3): 277-9. [PMID: 16992253]

Osborne, W. A. and S. Vincent (1900). "The physiological effects of extracts of nervous tissues." J Physiol 25(4): 283-94. [PMID: 16992534]

Paton, I. D. (1915). "On the Therapeutics of Organic Extracts." Br Med J 1(2823): 243-7. [PMID: 20767477]

Pugh, L. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 34-5. [PMID: 19984364]

Ray, M. B. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 44-7. [PMID: 19984369]

Richardson, K. C. and F. G. Young (1937). "The "pancreotropic" action of anterior pituitary extracts." J Physiol 91(3): 352-64. [PMID: 16994939]

Ross, E. J. (1955). "Insulin-like effect of anterior pituitary extract in accelerating the transfer of glucose across the blood-aqueous barrier." J Physiol 127(2): 247-51. [PMID: 14354668]

Schafer, E. A. and S. Vincent (1899). "The physiological effects of extracts of the pituitary body." J Physiol 25(1): 87-97. [PMID: 16992518]

Sheppard, J. B. (1923). "Organotherapy." J Natl Med Assoc 15(1): 31-3. [PMID: 20892005]

Sherrill, J. W. and E. F. Copp (1926). "Changes in Blood Serum Calcium Following the Administration of Parathyroid Extract." Cal West Med 24(2): 183-8. [PMID: 18739877]

Tattersall, R. (1995). "Pancreatic organotherapy for diabetes, 1889-1921." Med Hist 39(3): 288-316. [PMID: 7643671]

Thompson, R. L. (1906). "A Study of the Parathyroid Glandules in Paralysis agitans." J Med Res 15(3): 399-424 5. [PMID: 19971742]

Vincent, S. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 29-48. [PMID: 19984362]

Walker, K. (1925). "Special Discussion on Endocrine Therapy." Proc R Soc Med 18(Gen Rep): 38-41. [PMID: 19984366]