Magnet Therapy Abstracts 1

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Clinical observations on magnetic molecular energizing on Alzheimer's and Parkinson's patients and their possible association with heavy metals.
            (Nichols et al., 2000) Download
Magnetic Molecular Energizing (MME) is an IRB approved, experimental treatment consisting of two strong, non- pulsating DC electromagnets (5000 gauss) with the patient lying in a focal point between the two magnets.When the patient is treated with the MME device there is a temporary increase in the magnetic force on the atoms of the body in the focal point. The force results in a higher velocity of some of the orbiting electrons causes precession or wobble of the atom. Combined with the higher velocity this leads to enhanced electron transfer, which is the basis of all chemical reactions in the body. Seventeen patients with Parkinson's (PD) disease have been treated with nine definitely improving in symptoms(91-308 hrs). Seven Alzheimer's (AD) have been treated, with four (100-259 hrs) improving in cognition, and memory. Heavy metals appeared to be liberated from patients during the first several days of MME and the protocol now requires the administration of DMSA (Chemet 500 mg) before each treatment session to lessen side affects. Both Alzheimer's and Parkinson's have genetic as well as environmental factors in response to heavy metals in particular. Iron, calcium, aluminum, and mercury have been implicated in AD and iron and mercury in PD. Heavy metals increase oxidative stress via the Fenton reaction and cadmium, lead and mercury have demonstrated uncoupling of mitochondrial oxidative phosphorylation. MME is hypothesized to liberate heavy metals from the brain, up regulate cytoprotective enzymes and increase tissue regeneration.

Treatment of peripheral neuropathy with magnetic fields: A Peliminary Study.
            (Nichols et al., 2002) Download
Patients with peripheral neuropathy were placed under the MME, Magnetic Molecular Energizer, which produces a 5000 gauss DC electromagnetic field, with the subjects laying between two magnets under an IRB protocol. The focus of the MME was on the feet in three diabetic patients, knee in one, and LS spine in two. All patients had a baseline and post Current Perception Threshold (CPT) testing. CPT testing is an effective predictor of symptoms and physical impairment and is obtained with 3 neuroselective frequencies (5, 250 and 2000Hz) to test various nerve fiber types. This was obtained using double-blind testing methodology. (+/-20*micro*A, p<0.0006) Five patients showed significant improvement with MME therapy, and sustained in most cases more than 1 year. One patient had slight worsening regarding dysesthesiae. His CPT likewise worsened. Treatment times with MME ranged from 12 hrs. to 155 hrs. with a mean of 90 hours. The mechanisms underlying the observed favorable changes are not fully understood. Magnetic fields induce a higher velocity and precession of certain orbiting electrons resulting in enhanced electron transfer and chemical reactions. Human neuronal cell cuture, under 0.2T static magnetic fields after 15 min, induced vortexes of cells and exposed branched neurites featuring synaptic buttons. In conclusion, the sustained improvement infers that nerve regeneration was induced by the magnetic fields in the majority of these patients. In addition, the CPT changes esp. seen in patient W.Y. were dramatic, rarely seen in prior therapeutic trials, also suggestive of nerve regeneration.

Mitochondria of mice and men: moderate magnetic fields in obesity and fatty liver.
            (Nichols, 2012) Download
This paper reviews insulin resistance associated with fatty liver which accompanies the metabolic syndrome or diabetes from obesity. Until recently, one hypothesis that has received little attention is that mitochondrial defects are the cause of metabolic syndromes or diabetes 2, fatty liver and insulin resistance. Another hypothesis is that moderate magnetic fields change gene expression. Ob/Ob mice when treated with 0.5 T direct current electromagnetic fields were found to increase their activity, lose weight and fat in a 6 day period. Gene array analysis of human embryonic stem cells in another experiment of 0.23-0.28 T static magnetic fields was conducted. Up-regulation of genes for insulin factors genes, peroxisome proliferative activity receptor were increased, and calcium channel gene and other genes for mitochondrial ribosomal protein S, and uncoupling protein 2. Down-regulation of tumor necrosis factor alpha and interleukin 6 were demonstrated for this transformation. Forkhead transcription factors are also up-regulated at 5 days. Accelerated liver detoxification by moderate magnetic therapy of obesogens that disrupt homeostasis of metabolism of lipids ultimately resulting in obesity is another hypothesis.

Five ton standing magnet, its use in treating cerebral palsy.
            (Pearce et al., 2000) Download
Since treatment for many of the severely disabling neurologic disorders is symptomatic at best, therapies capable of regenerating tissues are needed. Preliminary clinical trials using a new magnetic device, the MME, show maintained symptom amelioration and disability reduction which suggests tissue regeneration. The device, similar to an open MRI scanner, generates a unidirectional 5000 gauss static magnetic field. The patient lies between two cones of the device. Changes in clinical status were scored according to an open label protocol after placement under the device for a specified period. Of an initial 114 patients receiving magnetic treatment 75 showed significant improvement. The most promising results were seen in cerebral palsy where 7 of 7 patients improved. A 40 year old patient, quadraplegic since birth, became ambulatory following 200 hours of treatment. In addition to gait improvement, the patient's scored neurologic evaluation showed significant changes in spasticity, motor performance, speech, and swallowing which were maintained for follow-up periods for over a year. Patients treated for Parkinson's disease, CNS injury, stroke, and MS also seemed to benefit. Among the explanations that might account for clinical improvement are that magnetic fields may have primary effects on circulation, oxygen uptake, and energy production. Another possibility is that magnetic fields activate stem cells resulting in enhanced tissue regeneration. Double blind studies are planned to further assess the therapeutic potential of the MME.

Effect of BEMER magnetic field therapy on the level of fatigue in patients with multiple sclerosis: a randomized, double-blind controlled trial.
            (Piatkowski et al., 2009) Download
OBJECTIVES:  Electromagnetic field therapy has been reported to be beneficial in patients with multiple sclerosis (MS) with significant fatigue. This study was designed to evaluate the long-term effects of Bio-Electro-Magnetic-Energy-Regulation (BEMER) on MS-related fatigue. DESIGN:  This was a monocenter, patient- and rater-blinded, placebo-controlled trial. PATIENTS:  There were 37 relapsing-remitting patients with MS with significant fatigue in the study. INTERVENTION:  The intervention consisted of BEMER magnetic field treatment for 8 minutes twice daily in comparison to placebo for 12 weeks. OUTCOME MEASURES:  The primary outcome criterion was change in the Modified Fatigue Impact Scale (MFIS) between baseline and 12 weeks. The secondary outcome criteria were changes of the Fatigue Severity Scale (FSS), a general depression scale-long version (ADS-L), Multiple Sclerosis Functional Scale (MSFC), and the Expanded Disability Status Scale (EDSS). RESULTS:  There was evidence of a significant difference of MFIS value (primary outcome criterion) after 12 weeks in favor of the verum group (26.84 versus 36.67; p = 0.024). In addition, FSS values were significantly lower in the verum group after 12 weeks (3.5 versus 4.7; p = 0.016). After 6 weeks' follow-up, verum and placebo groups did not differ in experienced fatigue (MFIS, FSS). Regarding the subscales of the MFIS, there was a significant decrease in physical (p = 0.018) and cognitive (p = 0.041), but not in psychologic subscales only in the verum group regarding the timepoints baseline and 12 weeks. BEMER therapy was well tolerated. DISCUSSION:  In this pilot study, we were able to demonstrate a beneficial effect of BEMER intervention on MS fatigue. As this was only a pilot study, trials with more patients and longer duration are mandatory to describe long-term effects.


 

Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma.
            (Říhová et al., 2011) Download
We have investigated the effects of low-frequency pulsed electromagnetic field (LF-EMF) produced by BEMER device on experimental mouse T-cell lymphoma EL4 growing on conventional and/or athymic (nude) mice. Exposure to EMF-BEMER slowed down the growth of tumor mass and prolonged the survival of experimental animals. The effect was more pronounced in immuno-compromised nude mice compared to conventional ones. Acceleration of tumor growth was never observed. No measurable levels of Hsp 70 or increased levels of specific anti-EL4 antibodies were detected in the serum taken from experimental mice before and at different intervals during the experiment, i.e. before solid tumor appeared, at the time of its aggressive growth, and at the terminal stage of the disease. A significant synergizing antitumor effect was seen when EL4 tumor-bearing mice were simultaneously exposed to EMF-BEMER and treated with suboptimal dose of synthetic HPMA copolymer-based doxorubicin, DOX(HYD)-HPMA. Such a combination may be especially useful for heavily treated patients suffering from advanced tumor and requiring additional aggressive chemotherapy which, however, at that time could represent almost life-threatening way of medication.

Effects of weak, low-frequency pulsed electromagnetic fields (BEMER type) on gene expression of human mesenchymal stem cells and chondrocytes: an in vitro study.
            (Walther et al., 2007) Download
In vitro effects of electromagnetic fields appear to be related to the type of electromagnetic field applied. Previously, we showed that human osteoblasts display effects of BEMER type electromagnetic field (BTEMF) on gene regulation. Here, we analyze effects of BTEMF on gene expression in human mesenchymal stem cells and chondrocytes. Primary mesenchymal stem cells from bone marrow and the chondrocyte cell line C28I2 were stimulated 5 times at 12-h intervals for 8 min each with BTEMF. RNA from treated and control cells was analyzed for gene expression using the affymetrix chip HG-U133A. A limited number of regulated gene products from both cell types mainly affect cell metabolism and cell matrix structure. There was no increased expression of cancer-related genes. RT-PCR analysis of selected transcripts partly confirmed array data. Results indicate that BTEMF in human mesenchymal stem cells and chondrocytes provide the first indications to understanding therapeutic effects achieved with BTEMF stimulation.

 


References

Nichols, TW, et al. (2000), ‘Clinical observations on magnetic molecular energizing on Alzheimer’s and Parkinson’s patients and their possible association with heavy metals.’, Soc for Neuroscience, 26: A229 PubMed:
Nichols, TW, LA Pearce, and D Bonlie (2002), ‘Treatment of peripheral neuropathy with magnetic fields: A Peliminary Study.’, Soc for Neuroscience, PubMed:
Nichols, TW (2012), ‘Mitochondria of mice and men: moderate magnetic fields in obesity and fatty liver.’, Med Hypotheses, 79 (3), 287-93. PubMed: 22743025
Pearce, LA, et al. (2000), ‘Five ton standing magnet, its use in treating cerebral palsy.’, Soc for Neuroscience, 26: 255 PubMed:
Piatkowski, J, S Kern, and T Ziemssen (2009), ‘Effect of BEMER magnetic field therapy on the level of fatigue in patients with multiple sclerosis: a randomized, double-blind controlled trial.’, J Altern Complement Med, 15 (5), 507-11. PubMed: 19422286
Říhová, B, et al. (2011), ‘Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma.’, J Drug Target, 19 (10), 890-99. PubMed: 21981636
Walther, M, et al. (2007), ‘Effects of weak, low-frequency pulsed electromagnetic fields (BEMER type) on gene expression of human mesenchymal stem cells and chondrocytes: an in vitro study.’, Electromagn Biol Med, 26 (3), 179-90. PubMed: 17886005