Glaucoma – Articles 1

© 2011

C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma

            (Michael, Qamar et al. 2008) Download

PURPOSE: To determine whether or not there is an association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with disease in cohorts of primary open-angle glaucoma (POAG) and primary closed-angle glaucoma (PCAG) from Pakistan. METHODS: This was a prospective study consisting of 150 patients (90 POAG and 60 PCAG) and 70 control subjects. Genomic DNA was extracted from leukocytes of the peripheral blood. MTHFR C677T polymorphism analysis was performed by the polymerase chain reaction-restriction fragment length polymorphism (RFLP) technique. RESULTS: The prevalence of the MTHFR C/T genotype was 22.2% in POAG, 13.3% in PACG, and 18.6% in controls whereas the MTHFR T/T genotype was present solely in the PACG group (6.9%). The difference regarding the T/T genotype between PACG and controls was statistically significant (p<0.01). CONCLUSIONS: The MTHFR C677T polymorphism was found to be associated with PCAG but not POAG in patients of Pakistani origin.

Lifestyle, nutrition, and glaucoma

         (Pasquale and Kang 2009) Download

The only proven strategy to prevent primary open-angle glaucoma (POAG) is the use of ocular hypotensive therapy among people diagnosed with ocular hypertension. In this review, various modifiable lifestyle factors, such as exercise, diet, and cigarette smoking, that may influence intraocular pressure and that have been studied in relation to the risk of developing POAG are discussed. Epidemiologic studies on lifestyle factors are few, and the current evidence suggests that there are no environmental factors that are clearly associated with POAG; however, a few factors merit further study. This review also outlines future directions for research into the primary prevention of POAG.


Michael, S., R. Qamar, et al. (2008). "C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with primary closed angle glaucoma." Mol Vis 14: 661-5.

Pasquale, L. R. and J. H. Kang (2009). "Lifestyle, nutrition, and glaucoma." J Glaucoma 18(6): 423-8.