GMO Abstracts 3

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Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize

         (Seralini, Clair et al. 2012) Download

The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone (from 0.1 ppb in water), were studied 2 years in rats. In females, all treated groups died 2-3 times more than controls, and more rapidly. This difference was visible in 3 male groups fed GMOs. All results were hormone and sex dependent, and the pathological profiles were comparable. Females developed large mammary tumors almost always more often than and before controls, the pituitary was the second most disabled organ; the sex hormonal balance was modified by GMO and Roundup treatments. In treated males, liver congestions and necrosis were 2.5-5.5 times higher. This pathology was confirmed by optic and transmission electron microscopy. Marked and severe kidney nephropathies were also generally 1.3-2.3 greater. Males presented 4 times more large palpable tumors than controls which occurred up to 600 days earlier. Biochemistry data confirmed very significant kidney chronic deficiencies; for all treatments and both sexes, 76% of the altered parameters were kidney related. These results can be explained by the non linear endocrine-disrupting effects of Roundup, but also by the overexpression of the transgene in the GMO and its metabolic consequences.

Answers to critics: Why there is a long term toxicity due to a Roundup-tolerant genetically modified maize and to a Roundup herbicide

         (Seralini, Mesnage et al. 2013) Download

Our recent work (Seralini et al., 2012) remains to date the most detailed study involving the life-long consumption of an agricultural genetically modified organism (GMO). This is true especially for NK603 maize for which only a 90-day test for commercial release was previously conducted using the same rat strain (Hammond et al., 2004). It is also the first long term detailed research on mammals exposed to a highly diluted pesticide in its total formulation with adjuvants. This may explain why 75% of our first criticisms arising within a week, among publishing authors, come from plant biologists, some developing patents on GMOs, even if it was a toxicological paper on mammals, and from Monsanto Company who owns both the NK603 GM maize and Roundup herbicide (R). Our study has limits like any one, and here we carefully answer to all criticisms from agencies, consultants and scientists, that were sent to the Editor or to ourselves. At this level, a full debate is biased if the toxicity tests on mammals of NK603 and R obtained by Monsanto Company remain confidential and thus unavailable in an electronic format for the whole scientific community to conduct independent scrutiny of the raw data. In our article, the conclusions of long-term NK603 and Roundup toxicities came from the statistically highly discriminant findings at the biochemical level in treated groups in comparison to controls, because these findings do correspond in an blinded analysis to the pathologies observed in organs, that were in turn linked to the deaths by anatomopathologists. GM NK603 and R cannot be regarded as safe to date.

Adverse effects in a feeding study of a GM derived corn in rats

         (Berry 2013) Download

Comments on "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize"

         (Le Tien and Le Huy 2013) Download

We request a serious reconsideration of the recent paper by Seralini et al. alleging tumorigenesis in rats resulting from consumption of corn derived from crops improved through biotechnology

         (Robert, Lerayer et al. 2013) Download


References

Berry, C. (2013). "Adverse effects in a feeding study of a GM derived corn in rats." Food Chem Toxicol 53: 445-6. [PMID: 23142391]

Le Tien, D. and H. Le Huy (2013). "Comments on "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize"." Food Chem Toxicol 53: 443-4. [PMID: 23142394]

Robert, W., A. Lerayer, et al. (2013). "We request a serious reconsideration of the recent paper by Seralini et al. alleging tumorigenesis in rats resulting from consumption of corn derived from crops improved through biotechnology (Seralini et al., 2012)." Food Chem Toxicol 53: 455-6. [PMID: 23142392]

Seralini, G. E., E. Clair, et al. (2012). "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize." Food Chem Toxicol 50(11): 4221-31. [PMID: 22999595]

Seralini, G. E., R. Mesnage, et al. (2013). "Answers to critics: Why there is a long term toxicity due to a Roundup-tolerant genetically modified maize and to a Roundup herbicide." Food Chem Toxicol 53: 476-83. [PMID: 23146697]