Colchicine Abstracts 1 – Back Pain

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Colchicine use in the damaged disk syndrome (DDS). Report of 50 patients.
            (Rask, 1979) Download
Fifty patients with acute and chronic damaged disk syndromes responded (68% good or excellent results) to minimal colchicine usage (0.6 to 1.2 mg per day), indicating that more complicated measures may be avoided in many distressed patients who suffer from disk disease. The usefulness of colchicine is slightly better in the acute than in the chronic disk syndrome, but any disk-suffering patient deserves a therapeutic trial of this possibly valuable medicament, before progressing to more complex, invasive procedures.

Use of oral colchicine in low-back pain.
            (Rask, 1988) Download
Further proof of colchicine’s efficacy comes from a study comparing colchicine with indomethacin, which was presented at the convention of the American Academy of Orthopaedic Surgeons. This is only an abstract not listed in PubMed, and no study comparing colchicine with indomethacin was found on PubMed.
Yu, et al: 1988 Colchicine effectual and proven so in diskal disorders. Abstract. J Neurol Orthop Surg 9; 284, 1988.

The use of oral colchicine for low-back pain. A double-blind study.
            (Schnebel and Simmons, 1988) Download
The use of colchicine for the treatment of low-back pain has been controversial; however, recent studies have shown its effectiveness when used intravenously. Studies using oral colchicine alone are lacking. The purpose of this study is to evaluate in a prospective, double-blind fashion the use of oral colchicine in the treatment of low back pain. Group I patients (15) were treated with a placebo capsule, and Group II (12) patients were treated with a colchicine capsule prescribed in a "burst dose" regimen. Patients were evaluated at 1, 2, 4, 6, and 12 weeks with a mean followup of 12 weeks. Parameters studied included patient characteristics, compliance, the McCoy pain drawings, pain analogue scales, the Million scale and objective tests. In terms of therapeutic response, the study shows no statistically significant difference between oral colchicine and placebo. The colchicine group did have an increased number of side effects.

Intravenous colchicine for low-back pain: a double-blind study.
            (Simmons et al., 1990) Download
Colchicine, a drug used for centuries in the treatment of gout, has been reported to be effective for low-back pain due to disc disorders. A prospective, randomized, double-blind study evaluating the therapeutic effect of intravenous colchicine was conducted in a group of patients with low-back pain with symptoms originating less than 6 months previously. Each patient completed a questionnaire and a pain drawing. Laboratory studies including uric acid and sedimentation rate were performed, as was a detailed physical examination and lumbar thermography. All treatment parameters (including physical therapy, anti-inflammatory medications, and instructions) were constant except that each patient received either intravenous colchicine or intravenous saline. Results indicate a significant difference between the two groups, the intravenous colchicine group showing improvement in symptoms for a few hours or days over a 3-week course of treatment. However, the relief was often of short duration.

eHealth 2015 - Colchicine vs Indomethacin men
         Download
On Jul, 28, 2015: 899 male patients aged 48 who take the same drugs are studied in Colchicine vs Indomethacin. Drug effectiveness:

 

not at all

somewhat

moderate

high

very high

Colchicine

0.00%

22.22%

37.04%

18.52%

22.22%

Indomethacin

12.50%

31.25%

31.25%

18.75%

6.25%

      


eHealth 2015 - Colchicine vs Indomethacin women
         Download
On Jul, 28, 2015: 689 female patients aged 52 who take the same drugs are studied in Colchicine vs Indomethacin. Drug effectiveness:

 

not at all

somewhat

moderate

high

very high

Colchicine

0.00%

16.67%

50.00%

16.67%

16.67%

Indomethacin

0.00%

50.00%

25.00%

25.00%

0.00%

           
             

 

 


References

Rask, MR (1979), ‘Colchicine use in the damaged disk syndrome (DDS). Report of 50 patients.’, Clin Orthop Relat Res, (143), 183-90. PubMedID: 509824
——— (1988), ‘Use of oral colchicine in low-back pain.’, Spine (Phila Pa 1976), 13(10) (10), 1201. PubMedID: 2974628
Schnebel, BE and JW Simmons (1988), ‘The use of oral colchicine for low-back pain. A double-blind study.’, Spine (Phila Pa 1976), 13 (3), 354-57. PubMedID: 2968669
Simmons, JW, et al. (1990), ‘Intravenous colchicine for low-back pain: a double-blind study.’, Spine (Phila Pa 1976), 15 (7), 716-17. PubMedID: 2145645