Bilberry Abstracts 1

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Preventive medical treatment of senile cataract with vitamin E and anthocyanosides: clinical evaluation
            (Bravetti, 1989) Download
Bilberry extract (180 mg twice daily of a 25-percent anthocyanoside extract) was given with vitamin E, demonstrated arrested cataract formation in 48 of 50 patients with senile cortical cataracts.

Effect of fermented bilberry extracts on visual outcomes in eyes with myopia: a prospective, randomized, placebo-controlled study.
            (Kamiya et al., 2013) Download
PURPOSE:  To investigate clinically the effects of yeast-fermented bilberry extract on visual outcomes in myopic eyes. METHODS:  In a prospective, randomized, placebo-controlled, cross-over study, we examined 30 eyes of 30 middle-aged healthy volunteers (mean age±standard deviation, 39.5±7.2 years) with myopia [manifest spherical equivalent, -2.40±1.88 diopters (D)], who were randomly assigned to 1 of 2 oral regimens: fermented bilberry extract (400 mg/day) or placebo. We quantitatively assessed visual acuity, refraction, pupil constriction rate, accommodation, and mesopic contrast sensitivity (CS), before and 1 month after treatment. Only the right eyes were tested. The amplitude of accommodation and CS were measured with an accommodometer (D'ACOMO; WOC) and a CS unit (VCTS-6500; Vistech), respectively. From the CS, the area under the log contrast sensitivity function (AULCSF) was calculated. RESULTS:  The mean amplitude of accommodation increased significantly, from 4.62±1.88 D before treatment, to 5.33±2.03 D after treatment in the study group (Wilcoxon signed-rank test, P=0.002). Moreover, the mesopic AULCSF was significantly increased, from 1.04±0.16 before, to 1.13±0.17 after, treatment (P=0.009). However, we found no significant changes in accommodation or AULCSF in the control group (P>0.05), or any significant changes in any other parameters in either group (P>0.05). CONCLUSIONS:  The present data show that fermented bilberry extract is effective in causing increases in subjective accommodation and in mesopic CS in myopic eyes.


 

The effect of bilberry nutritional supplementation on night visual acuity and contrast sensitivity
            (Muth et al., 2000) Download
PURPOSE: The purpose of this study was to investigate the effect of bilberry on night visual acuity (VA) and night contrast sensitivity (CS). METHODS: This study utilized a double-blind, placebo-controlled, crossover design. The subjects were young males with good vision; eight received placebo and seven received active capsules for three weeks. Active capsules contained 160 mg of bilberry extract (25-percent anthocyanosides), and the placebo capsules contained only inactive ingredients. Subjects ingested one active or placebo capsule three times daily for 21 days. After the three-week treatment period, a one-month washout period was employed to allow any effect of bilberry on night vision to dissipate. In the second three-week treatment period, the eight subjects who first received placebo were given active capsules, and the seven who first received active capsules were given placebo. Night VA and night CS was tested throughout the three-month experiment. RESULTS: There was no difference in night VA during any of the measurement periods when examining the average night VA or the last night VA measurement during active and placebo treatments. In addition, there was no difference in night CS during any of the measurement periods when examining the average night CS or the last night CS measurement during active and placebo treatments. CONCLUSION: The current study failed to find an effect of bilberry on night VA or night CS for a high dose of bilberry taken for a significant duration. Hence, the current study casts doubt on the proposition that bilberry supplementation, in the forms currently available and in the doses recommended, is an effective treatment for the improvement of night vision in this population.

Diabetic and hypertensive retinopathy therapy with Vaccinium myrtillus anthocyanosides (Tegens®): Double-blind, placebo-controlled clinical trial
            (Perossini et al., 1987) Download
In a double-blind study, 14 patients with diabetic and/or hypertensive retinopathy were supplemented with bilberry extract equivalent to 115 mg anthocyanosides daily (or placebo) for one month. Significant improvements were observed in the ophthalmoscopic parameters of 11 subjects receiving bilberry, and 12 patients showed improvement in angiographic parameters.

 

 


References

Bravetti, G (1989), ‘Preventive medical treatment of senile cataract with vitamin E and anthocyanosides: clinical evaluation’, Ann Ottalmol Clin Ocul, PubMedID:
Kamiya, K, et al. (2013), ‘Effect of fermented bilberry extracts on visual outcomes in eyes with myopia: a prospective, randomized, placebo-controlled study.’, J Ocul Pharmacol Ther, 29 (3), 356-59. PubMedID: 23113643
Muth, E. R., J. M. Laurent, and P. Jasper (2000), ‘The effect of bilberry nutritional supplementation on night visual acuity and contrast sensitivity’, Altern Med Rev, 5 (2), 164-73. PubMedID: 10767671
Perossini, M, et al. (1987), ‘Diabetic and hypertensive retinopathy therapy with Vaccinium myrtillus anthocyanosides (Tegens®): Double-blind, placebo-controlled clinical trial’, Ann Ottalmol Clin Ocul, PubMedID: