Adenosine Abstracts 9

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Herpesvirus infection.
            (Sklar, 1977) Download

Herpes zoster. The treatment and prevention of neuralgia with adenosine monophosphate
            (Sklar et al., 1985) Download
Thirty-two adults were enrolled in a randomized, placebo-controlled double-blind trial of intramuscular injections of gel-sustained adenosine monophosphate (AMP) given three times a week for up to four weeks for acute herpes zoster. Adenosine monophosphate moderately reduced the pain soon after the start of treatment, decreased desquamation time, and promoted faster healing of the skin than placebo treatment. Adenosine monophosphate treatment reduced virus shedding and cleared the virus faster than in placebo-treated subjects. At the end of the initial four-week treatment period, 88% of AMP-treated patients were pain free, as opposed to only 43% in the placebo group. After four weeks, all patients who had not recovered from pain started receiving AMP treatment without breaking the code. All these patients recovered from pain within three weeks after initiation of treatment. No recurrence of pain or lesions was experienced from three to 18 months after the end of treatment. Adenosine monophosphate, a natural cellular metabolite, showed no side effects or toxicity during and after the treatment.

The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP.
            (Kakei et al., 1986) Download
ATP-sensitive K+ channels in inside-out membrane patches from dispersed rat pancreatic B-cells were studied using patch-clamp methods. The dose-response curve for ATP-induced channel inhibition was shifted to higher concentrations in the presence of ADP (2 mM). In glucose-free solution, the total intracellular concentration of ATP was 3.8 mM and of ADP 1.5 mM; glucose (20 mM) increased ATP and decreased ADP by approx. 40%. These results suggest that both ADP and ATP may be involved in regulating the activity of the glucose-sensitive K+ channel in intact B-cells.

 

References

Kakei, M, et al. (1986), ‘The ATP-sensitivity of K+ channels in rat pancreatic B-cells is modulated by ADP.’, FEBS Lett, 208 (1), 63-66. PubMedID: 2429869
Sklar, S. H., et al. (1985), ‘Herpes zoster. The treatment and prevention of neuralgia with adenosine monophosphate’, JAMA, 253 (10), 1427-30. PubMedID: 3968773
Sklar, SH (1977), ‘Herpesvirus infection.’, JAMA, 237(9) (9), 871-72. PubMedID: 189100